While I was googling something I found something awesome by mistake. It's a podcast called "The Thrilling Adventure Hour" It's like A Prairie Home Companion meets the Goon Show. I found an NPR Story on it here. They've had guest stars like Nathan Fillion (Firefly), Neil Patrick Harris (Doctor Horrible), Danny Pundi (Community), and Jorge Garcia (Lost).
Check it out here: http://thrillingadventurehour.com